Single Molecules
Single Particles
Membrane Transport

Ulrich F. Keyser et al.

All publications


Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.

We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information on JOBS and TENTATIVE projects below .

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Recent Publications

V.V. Thacker, L. O. Hermann, D. O. Sigle, T. Zhang, J. J. Baumberg, and U. F. Keyser.
DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering
Nature communications
, 5:3448, 2014. [ DOI | .html ]

S. Hernandez-Ainsa, K. Misiunas, V. V. Thacker, E. A. Hemmig, and U. F. Keyser.
Voltage dependent properties of DNA origami nanopores
Nano Letters
, published online, 2014. [ DOI | http ]

H. Gaimster, J. Cama, S. Hernandez-Ainsa, U. F. Keyser, and D. K. Summers.
The indole pulse: a new perspective on indole signalling in escherichia coli
, 9(4):e93168, 2014. [ DOI | http ]

J. R. Burns, K. Goepfrich, J. W. Wood, V. V. Thacker, E. Stulz, U. F. Keyser, and S. Howorka.
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor (published as HOT PAPER, Cover article)
Angewandte Chemie International Edition
, 52(46):12069-12072, 2013. [ DOI | http ]

N. Laohakunakorn, B. Gollnick, F. Moreno-Herreo, D. G. A. L. Aart, R. P. A Dullens, S. Ghosal, and U. F. Keyser.
A Landau-Squire nanojet
Nano Letters
, 13(11):5141-5146, 2013. [ DOI | http ]

S. Hernandez-Ainsa, N. A. W. Bell, V. V. Thacker, K. Goepfrich, K. Misiunas, M. Fuentes-Perez, F. Moreno-Herrero, and U. F. Keyser.
DNA origami nanopores for controlling DNA translocation
ACS nano
, 7(7):6024-6030, 2013. [ DOI | http ]

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Recent Highlights


Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor . (Angewandte Chemie)

Press release: U Cambridge
Coverage: azonano , e!science , sciencedaily , eurekalert , cambridgenetwork ,
Image 01

Rapid internal contraction boosts DNA friction. (nature communications)

Image 02

DNA origami nanopores. (Nano Letters)

Hernandez ACS nano highlighted on Genome Web
Li, Bell ACS nano highlighted on NanoWerk
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