Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.
We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information on JOBS and TENTATIVE projects below .
V.V. Thacker, L. O. Hermann, D. O. Sigle, T. Zhang, J. J. Baumberg, and U. F.
DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering.
Nature communications, 5:3448, 2014. [ DOI | .html ]
J. R. Burns, K. Goepfrich, J. W. Wood, V. V. Thacker, E. Stulz, U. F. Keyser,
and S. Howorka.
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor (published as HOT PAPER, Cover article).
Angewandte Chemie International Edition, 52(46):12069-12072, 2013. [ DOI | http ]
S. Hernandez-Ainsa, N. A. W. Bell, V. V. Thacker, K. Goepfrich, K. Misiunas,
M. Fuentes-Perez, F. Moreno-Herrero, and U. F. Keyser.
DNA origami nanopores for controlling DNA translocation.
ACS nano, 7(7):6024-6030, 2013. [ DOI | http ]
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor . (Angewandte Chemie)Press release: U Cambridge
Rapid internal contraction boosts DNA friction. (nature communications)
DNA origami nanopores. (Nano Letters)