Our main research is focused on understanding and controlling transport processes through membranes of both biological and technological origin. We are interested in the physics of macromolecules and particles in confined geometries at the single-molecule and single-particle level. For this, we employ a wide range of techniques (DNA origami self-assembly, optical tweezers, particle tracking, fluorescence microscopy, electrophysiology, micro-/nanofluidics) to exert maximum control over all parameters in the experiment.
The improvement and development of new measurement and sensing techniques based on a combination of single molecule approaches is another major interest of our group. Our interdisciplinary research combines physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.
If you are interested in working with us, you can find more information of JOBS and OPEN PROJECTS below.
J. R. Burns, K. Goepfrich, J. W. Wood, V. V. Thacker, E. Stulz, U. F. Keyser,
and S. Howorka.
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor (published as HOT PAPER, Cover Article).
Angewandte Chemie International Edition, published online, 2013. [ DOI | http ]
S. Hernandez-Ainsa, N. A. W. Bell, V. V. Thacker, K. Goepfrich, K. Misiunas,
M. Fuentes-Perez, F. Moreno-Herrero, and U. F. Keyser.
DNA origami nanopores for controlling DNA translocation.
ACS nano, 7(7):6024-6030, 2013. [ DOI | http ]
N. A. W. Bell, , V. V. Thacker, S. Hernandez-Ainsa, M. Fuentes-Perez, F. Moerno-Herrero, T. Liedl, and U. F. Keyser.
Multiplexed ionic current sensing with glass nanopores.
Lab on a Chip, 13:1859-1862, 2013. [ DOI ]
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor . (Angewandte Chemie)
Rapid internal contraction boosts DNA friction. (nature communications)
DNA origami nanopores. (Nano Letters)