Our main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule/-particle level. We thrive to exert maximum control over all parameters in the experiment using techniques like: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics. In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches. Our interdisciplinary team combines people with expertise in physics, physical chemistry, biochemistry/biology, and micro-/nanofabrication.
We are always looking for enthusiastic students and postdocs. If you are interested in working with us, you can find more information on JOBS and TENTATIVE projects below .
K. D. Schleicher, S. L. Dettmer, L. E. Kapinos, S. Pagliara, U. F. Keyser,
S. Jeney, and R. Y. H. Lim.
Selective Transport Control on Molecular Velcro Made From Intrinsically Disordered Proteins.
Nature Nanotechnology, published online, 2014. [ DOI | www: ]
S. Pagliara, K. Franze, C. R. McClain, G. W. Wylde, C. L. Fisher, R. J. M.
Franklin, A. J. Kabla, U. F. Keyser, and K. J. Chalut.
Auxetic nuclei in embryonic stem cells exiting pluripotency.
Nature Materials, 13:638-644, 2014. [ DOI | .html ]
J. Cama, C. Chimerel, S. Pagliara, A. Javer, and U. F. Keyser.
A label-free microfluidic assay to quantitatively study antibiotic diffusion through lipid membranes.
Lab Chip, published online, 2014. [ DOI | www: ]
V.V. Thacker, L. O. Hermann, D. O. Sigle, T. Zhang, J. J. Baumberg, and U. F.
DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering.
Nature communications, 5:3448, 2014. [ DOI | .html ]
J. R. Burns, K. Goepfrich, J. W. Wood, V. V. Thacker, E. Stulz, U. F. Keyser,
and S. Howorka.
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor (published as HOT PAPER, Cover article).
Angewandte Chemie International Edition, 52(46):12069-12072, 2013. [ DOI | http ]
Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor . (Angewandte Chemie)Press release: U Cambridge
DNA origami nanopores. (Nano Letters)