Yan Yan Shery Huang

Biointerface

Dr Yan Yan Shery Huang
University Lecturer in Bioengineering

Director of Studies in Physics, Homerton College
E-mail: yysh2 (then cam.ac.uk after [a])

Research keywords: Bioengineering, Tissue Engineering, Cell Niche Model, Biofabrication, Bioelectronics


My group is interested in designing and developing biomimetic niche for tissue engineering, and organ-on-chip for pathology models and high-throughput drug testing.
Living tissues are intricate ensembles of multiple cell types embedded in a complex, but well-defined extracellular matrix (ECM) of topographical and adhesive features ranging from nanometres to micrometres. Cell ladened ECMs act like units of reaction centres and information hubs. Corporation between these small units lead to a hierarchical structure (i.e. a human body) acheiving homeostasis (balance).

We combine nanotechnology and new material fabrication techniques to construct the defined biochemical and physical inputs of an ECM scaffold, and to recapitulate the key attributes of a 'niche' unit. Our research is highly multi-disciplinary in nature, crossing fields of physics, engineering, biology, material chemistry, and computer science. We aim to translate our scientific findings into exploring a new generation of tissue engineering constructs for personalised therapy, at affordable costs; and to provide new solutions for disease monitoring, drug testing, and better patient healthcare.